STAT3 inhibitor C188 ( C188; C-188; C 188; STAT3-IN-C188; Cpd188; Cpd-188 )

Catalog No. M16058 CAS No. 823828-18-8

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Product Name

STAT3 inhibitor C188
Note

Research use only, not for human use.
Brief Description

A potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM).
Description

A potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM) and inhibits IL-6-mediated phosphorylation of STAT3; inhibits nuclear translocation of phosphorylated Stat3 with IC50 of 39 uM, induces apoptosis preferentially of breast cancer cell lines with constitutive Stat3 activation.
Synonyms

C188; C-188; C 188; STAT3-IN-C188; Cpd188; Cpd-188
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

——
Indication

——

CAS Number

823828-18-8
Formula Weight

433.45
Molecular Formula

C19H15NO7S2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)C1=CC=C(S(=O)(NC2=C3C=CC=CC3=C(O)C(SCC(O)=O)=C2)=O)C=C1
Chemical Name

4-(N-(3-((carboxymethyl)thio)-4-hydroxynaphthalen-1-yl)sulfamoyl)benzoic acid

1. Xu X, et al. PLoS One. 2009;4(3):e4783.

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